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Updated: Aug 19, 2026

Recording Temperature-induced Neuronal Activity through Monitoring Calcium Changes in the Olfactory Bulb of Xenopus laevis
Published on: June 3, 2016
The ins and outs of intracellular chloride in olfactory receptor neurons
1Department of Cell and Developmental Biology, Rocky Mountain Taste and Smell Center, School of Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA.
Abstract:
Stimulation of olfactory receptor neurons with odors culminates in opening of a ciliary Ca2+-activated Cl- channel. Because intracellular Cl- ([Cl-]i) is above electrochemical equilibrium in these cells, the result is cell depolarization that triggers action potentials that carry information to the olfactory bulb. In this issue of Neuron, Reisert and coworkers use combined pharmacological and mouse genetic approaches to show that the transporter responsible for maintaining Cl- above electrochemical equilibrium is NKCC1, a (Na+)(2Cl-)(K+) cotransporter found in other tissues, including neurons.
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