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[Central origin on the excito-motric action of morphine on intestine]
Abstract:
In ewew fitted with a cerebro-ventricular cannula and equipped with extra-cellular bipolar electrodes on the antrum and proximal small intestine, an intraventricular injection of morphine at a dose (40 micrograms/kg) ineffective peripherally was followed within 1 min by an increased spike activity of the duodenum without disruption of the occurrence of migrating myoelectric complexes. This effect was paralleled by a reduction of antral motility and abolished by small intraventricular doses of nalorphine. After an intravenous injection of large doses of the drug drug (0.8 mg/kg), spike activity was increased at both jejunal and duodenal level without changes in the antrum and followed by a long-lasting disorganization of the motor profile. The results suggested a centrally mediated gastro-duodenal effect of morphine.
Insights
Central administration of morphine increases duodenal motility and reduces antral contractions, suggesting a brain-mediated effect on the gastrointestinal system. This centrally induced gastro-duodenal response was reversed by nalorphine.
Area of Science:
- Neurogastroenterology
- Pharmacology
- Gastrointestinal Physiology
Context:
- Investigating the central nervous system's influence on gastrointestinal motility.
- Understanding the mechanisms of opioid action on the gut.
Purpose:
- To determine if centrally administered morphine affects gastrointestinal motility.
- To characterize the effects of central versus peripheral morphine administration on duodenal and antral activity.
Summary:
- Intraventricular morphine (40 µg/kg) increased duodenal spike activity and reduced antral motility within 1 minute, without altering migrating myoelectric complexes. This effect was blocked by intraventricular nalorphine.
- Intravenous morphine (0.8 mg/kg) increased jejunal and duodenal spike activity but did not affect antral motility, leading to long-term motor pattern disruption.
- These findings suggest a centrally mediated gastro-duodenal effect of morphine.
Impact:
- Highlights the role of central pathways in mediating morphine's effects on the gut.
- Provides insights into the differential effects of central and peripheral opioid administration on gastrointestinal function.
- Suggests potential therapeutic targets for managing gastrointestinal motility disorders.