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Related Experiment Videos

Human papillomavirus type 16 E2 and E6/E7 variants.

David C Swan1, Mangalathu Rajeevan, Guillermo Tortolero-Luna

  • 1U.S. Department of Health and Human Services, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Atlanta, GA 30333, USA. dswan@cdc.gov

Gynecologic Oncology
|February 22, 2005
PubMed
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New human papillomavirus (HPV) type 16 polymorphisms were identified, revealing linkage between E2 and E6/E7 regions. This allows for variant classification using a short E6 sequence, aiding in understanding cervical disease risk.

Area of Science:

  • Virology
  • Genetics
  • Oncology

Background:

  • Human papillomavirus (HPV) type 16 exhibits geographic variations, classified into European, African, Asian, and Asian-American prototypes.
  • Certain HPV16 variants are associated with an increased risk of cervical disease.

Purpose of the Study:

  • To identify novel HPV16 polymorphisms.
  • To determine the genetic linkage between the E2 and E6/E7 regions of HPV16.
  • To establish the minimal sequence required for accurate HPV16 variant classification.

Main Methods:

  • Sequencing of the complete E2, E6, and E7 regions in HPV16-positive cervical samples from a case-control study.
  • Analysis of a cohort of 100 HPV16-positive cervical samples.

Main Results:

Related Experiment Videos

  • One novel synonymous polymorphism (T3205A) was identified in the E2 region.
  • HPV16 variant distribution included European (37), E-G350 (27), Asian-American (16), African1 (5), African2 (2), E-C109G (8), E-G131G (3), and Asian (2).
  • The E7 region showed less variation compared to E6 and E2 regions.

Conclusions:

  • Genetic changes in the E2 region were consistently linked to corresponding changes in the E6/E7 regions, with no evidence of recombination.
  • The established linkage permits HPV16 variant classification based on a minimal E6 sequence (nucleotides 109-350).