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Calcium binding in cardiac sarcolemma.

N C Morcos, A L Jacobson

    Canadian Journal of Physiology and Pharmacology
    |May 1, 1979
    PubMed
    Summary

    Calcium binding to guinea pig cardiac sarcolemma depends on both calcium and ATP concentrations. ATP influences calcium binding differently at low and high calcium levels, suggesting distinct binding mechanisms.

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    Area of Science:

    • Biochemistry
    • Cardiovascular Physiology

    Background:

    • Cardiac sarcolemma plays a crucial role in regulating intracellular calcium levels.
    • Understanding calcium and ATP interactions is vital for cardiac function.

    Purpose of the Study:

    • To investigate the relationship between calcium binding and ATPase activity in guinea pig cardiac sarcolemma.
    • To determine the influence of calcium ion and ATP concentrations on calcium binding.

    Main Methods:

    • Investigated calcium binding to cardiac sarcolemma.
    • Assessed ATPase activities (Ca2+-stimulated MgATPase, MgATPase, CaATPase) using inhibitor studies.
    • Varied concentrations of calcium ions and ATP.

    Main Results:

    • Calcium and ATP concentrations were key factors in calcium binding.
    • At saturating ATP, calcium binding was 50% ATP-dependent at 0.1 mM calcium and 20% ATP-dependent at 10 mM calcium.
    • ATP-dependent calcium binding involved one class of sites, while non-ATP-dependent binding involved two classes.
    • Inhibitor studies suggested Ca2+ and Mg2+ interact with different sites or enzymes.

    Conclusions:

    • Calcium binding to cardiac sarcolemma is modulated by both calcium and ATP concentrations.
    • Distinct binding sites and mechanisms exist for ATP-dependent and non-ATP-dependent calcium binding.
    • Further research is needed to clarify the interaction of Ca2+ and Mg2+ with sarcolemmal enzymes.

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