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Multiple roads to the aging phenotype: insights from the molecular dissection of progerias through DNA microarray

Tomas A Prolla1

  • 1Department of Genetics, University of Wisconsin-Madison, 445 Henry Mall, Madison, WI 53705, USA. taprolla@facstaff.wisc.edu

Mechanisms of Ageing and Development
|February 22, 2005
PubMed
Abstract

No abstract available in PubMed .

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DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...