Related Experiment Video
Updated: Aug 19, 2026

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
Published on: August 10, 2012
Tyrosine hydroxylase Val-81-Met polymorphism associated with early-onset alcoholism
Norbert Dahmen1, Markus Völp, Peter Singer
1Department of Psychiatry, University of Mainz, Germany. ndahmen@psychiatrie.klinik.uni-mainz.de
Abstract:
The present study examined the association of the Tyrosine hydroxylase Val-81-Met polymorphism with alcohol dependence. One hundred and fifty-nine patients in a psychiatric unit with alcohol dependence were genotyped as well as 92 healthy volunteers. The Val allele was more frequent in patients with alcohol dependence (69.5%) than in controls (62.5%). This effect was largely due to the association with early-onset alcoholism (77.8%), whereas no difference was noted between late-onset patients and controls. Our results suggest a role for tyrosine hydroxylase in early-onset alcoholism.
Related Concept Videos
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Inborn Errors of Metabolism
Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase
Pharmacogenetics of Drug Metabolism: Overview
Type II Diabetes I: Introduction
Pharmacogenetics of Phase I Enzymes: Cytochrome P450 Isozymes

