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Par-3 controls tight junction assembly through the Rac exchange factor Tiam1

Xinyu Chen1, Ian G Macara

  • 1Center for Cell Signaling, Department of Microbiology, HSC, University of Virginia, Charlottesville, Virginia 22908, USA. xc2d@virginia.edu

Nature Cell Biology
|February 22, 2005
PubMed
Summary

Partitioning-defective 3 (Par-3) is crucial for mammalian epithelial cell tight junction assembly. Its absence causes Rac activation, which can be reversed by inhibiting Rac, revealing a novel polarity mechanism.

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