Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fine-scale recombination patterns differ between chimpanzees and humans.

Susan E Ptak1, David A Hinds, Kathrin Koehler

  • 1Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6 04103, Leipzig, Germany. ptak@email.eva.mpg.de

Nature Genetics
|February 22, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic diversity of late Neanderthals in northwestern Europe.

Nature·2026
Same author

What sets the mutation rate of a cell type in an animal species?

PLoS biology·2026
Same author

Sex differences in transcription-associated mutagenesis in the human germline.

Genetics·2026
Same author

A sibling study of variation in parental mutation rates.

bioRxiv : the preprint server for biology·2026
Same author

Genetics of growth rate in induced pluripotent stem cells.

Stem cell reports·2026
Same author

Admixture mapping identifies complex trait associations with local ancestry in the <i>All of Us Research Program</i>.

medRxiv : the preprint server for health sciences·2026
Same journal

Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complex.

Nature genetics·2026
Same journal

Spatial transcriptomic analyses highlight distinct erythroid niches in mice and humans.

Nature genetics·2026
Same journal

Building up pangenome analysis block by block.

Nature genetics·2026
Same journal

Mutations in splicing factor gene U2AF1 rescue defective oncogene splicing in KRAS-mutant cancers.

Nature genetics·2026
Same journal

Assessing the effect of immune surveillance on clonal expansions in the blood.

Nature genetics·2026
Same journal

Improved heritability partitioning and enrichment analyses using summary statistics with graphREML.

Nature genetics·2026
See all related articles

Human and chimpanzee genomes show significant differences in recombination rates and hotspots. This suggests the recombination landscape has changed considerably between these closely related species.

Area of Science:

  • Genomics
  • Evolutionary Biology
  • Population Genetics

Background:

  • Recombination rates vary significantly across the human genome, with hotspots showing 10-1,000 times higher rates than background levels.
  • Understanding how recombination rates evolve over time and across species is crucial for evolutionary studies.

Purpose of the Study:

  • To investigate the conservation of recombination rates and hotspots between humans and chimpanzees.
  • To determine the extent to which the recombination landscape has changed between these species.

Main Methods:

  • Estimated recombination rates using 14 Mb of linkage disequilibrium data.
  • Analyzed data from central chimpanzee and human populations.

Main Results:

Related Experiment Videos

  • Recombination hotspots are not conserved between human and chimpanzee populations.
  • Recombination rates in larger genomic regions (50 kb) show only weak conservation.
  • The overall recombination landscape has markedly changed between the two species.

Conclusions:

  • Recombination patterns are highly dynamic and not strictly conserved even between closely related species.
  • Significant evolutionary changes in recombination rates have occurred since the divergence of humans and chimpanzees.