Related Experiment Video
Updated: Aug 5, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
Published on: April 1, 2015
Oxidatively modified fibrinogen modulates blood rheological parameters
E V Roitman1, O A Azizova, Yu A Morozov
1Russian Scientific Center of Surgery, Russian Academy of Medical Sciences, Moscow, Russia.
Abstract:
We studied the effect of UV-oxidized fibrinogen with oxidation degrees of 10 and 20% on rheological parameters of the blood. The effect of fibrinogen with 10% oxidation degree was moderate and variable, which attests to its partial compensation with the pool of natural antioxidants. The effect of fibrinogen with 20% oxidation degree was more pronounced. It dramatically decreased deformability of erythrocytes, delayed formation of linear aggregates, accelerated formation of 3D-aggregates, enhanced the total hydrodynamic strength of aggregates, but decreased stability of the largest aggregates. It did not increase plasma viscosity, but enhanced viscosity of the blood at all shear rates. At both degrees of oxidation, suspension stability of the blood decreased, the Caisson viscosity did not change, and the difference between the values of Caisson and asymptotic viscosities markedly increased. On the whole, oxidative fibrinogen produces negative changes in blood rheological parameters, and its effect depends on the degree of oxidation.
More Related Videos
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Clot Retraction and Fibrinolysis

