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Updated: Jul 13, 2026

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling

Published on: May 31, 2011

Noise reduction in multi-slice arterial spin tagging imaging.

K S St Lawrence¹, J A Frank, P A Bandettini

¹Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. kstlaw@lri.sjhc.london.on.ca

Magnetic Resonance in Medicine

|February 22, 2005

Summary

A new multi-slice arterial spin tagging (ASSIST) method enables simultaneous cerebral blood flow and BOLD imaging. This technique improves perfusion signal stability, reducing susceptibility to physiological noise.

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Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling

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Published on: May 31, 2024

Area of Science:

Magnetic Resonance Imaging
Neuroimaging
Physiology

Background:

Arterial spin tagging (ASSIST) is a technique for 3D imaging of cerebral blood flow.
Simultaneous acquisition of cerebral blood flow and BOLD data is desirable for comprehensive brain function assessment.

Purpose of the Study:

To develop and validate a multi-slice version of ASSIST for simultaneous cerebral blood flow and BOLD data acquisition.
To evaluate the performance and stability of the multi-slice ASSIST sequence.

Main Methods:

A multi-slice ASSIST sequence was developed, incorporating multiple inversion pulses for static signal suppression and background suppression across slices.
The sequence was tested by simultaneously acquiring ASSIST and BOLD data during functional tasks and collecting resting-state ASSIST data.

Main Results:

The multi-slice ASSIST sequence successfully enabled simultaneous collection of cerebral blood flow and BOLD data.
Perfusion signal temporal stability was found to be 60% greater at 3 T compared to 1.5 T.
The improved stability was attributed to ASSIST's insensitivity to physiological noise.

Conclusions:

The multi-slice ASSIST sequence is a valuable tool for simultaneous neuroimaging of cerebral blood flow and BOLD signals.
This technique offers enhanced temporal stability and reduced physiological noise, particularly at higher magnetic field strengths.