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Related Experiment Videos

Umbilical metastases: current viewpoint.

Raimondo Gabriele1, Marco Conte, Federico Egidi

  • 1Department of Surgery, "P,Valdoni" – University of Rome "La Sapienza", Rome, Italy. raimondo.gabriele@uniroma1.it.

World Journal of Surgical Oncology
|February 23, 2005
PubMed
Summary
This summary is machine-generated.

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Sister Mary Joseph's nodule, an umbilical metastasis, is a rare sign of advanced cancer, often from the GI or GU tract. Early evaluation and aggressive treatment may improve patient survival.

Area of Science:

  • Oncology
  • Surgical Pathology

Background:

  • Umbilical metastases, known as Sister Mary Joseph's nodules, are rare but significant indicators of advanced malignancy.
  • Historically associated with a poor prognosis, these nodules warrant thorough investigation.

Purpose of the Study:

  • To review the current understanding of umbilical metastases.
  • To discuss the epidemiology, clinical presentation, pathophysiology, and treatment of Sister Mary Joseph's nodules.

Main Methods:

  • Literature search of PubMed using terms related to umbilical metastases and Sister Mary Joseph's nodule.
  • Analysis of 20 English-language articles and cross-references.

Main Results:

  • Primary malignancies often originate from the gastrointestinal or genitourinary tracts.

Related Experiment Videos

  • Umbilical metastases can be the initial sign of an occult primary tumor.

    • Conclusions:

    • All umbilical lesions require careful evaluation, including biopsy if indicated.
    • Aggressive surgical and chemotherapeutic approaches may enhance survival for affected patients.