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Causes of lead toxicity in a Nigerian city
N J Wright1, T D Thacher, M A Pfitzner
1Las Vegas Clinic for Children and Youth, 501 7th Street, Las Vegas, New Mexico 87701, USA.
Background:
Up to 70% of young Nigerian children have been reported to have blood lead concentrations > or =10 microg/dl.
Aims:
To better elucidate risk factors for lead toxicity among Nigerian families with children at risk for lead toxicity.
Methods:
Two geographic wards in Jos, Nigeria were selected for study, one previously reported to have a high mean blood lead level (37 (SD 13) microg/dl) and one with a lower mean blood lead level (17 (SD 10) microg/dl) in young children. Data pertaining to potential risk factors for lead exposure were collected from children and adults in 34 households.
Results:
The mean (SD) blood lead concentration of 275 subjects, aged 3 weeks to 90 years, was 8.7 (5.7) microg/dl (range 1-34 microg/dl); 92 (34%) had concentrations > or =10 microg/dl. In multivariate analysis, an age of 5 years and under, flaking house paint, residence near a gasoline seller, male gender, increasing maternal and paternal education, and use of a lead ore eye cosmetic were independently associated with greater blood lead concentration. Vehicle ownership was associated with reduced lead concentration. Compared with the low-lead ward, residence in the high-lead ward remained significantly associated with greater lead values, indicating that additional factors likely contribute to lead exposure.
Conclusion:
Although the cause of increased lead levels in Jos appears to be multi-factorial, several remediable sources contribute to lead exposure in Nigeria.
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