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Related Experiment Videos

Fetal plasma testosterone correlates positively with cortisol.

R Gitau1, D Adams, N M Fisk

  • 1Wolfson and Weston Research Centre for Family Health, Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Road, London W12 0NN, UK.

Archives of Disease in Childhood. Fetal and Neonatal Edition
|February 23, 2005
PubMed
Summary

Fetal testosterone levels are influenced by maternal testosterone and fetal cortisol. Higher fetal testosterone was observed in males and increased with gestational age in females, unlike in adults.

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Area of Science:

  • Endocrinology
  • Developmental Biology
  • Reproductive Health

Background:

  • Fetal testosterone exposure is linked to childhood behavior programming.
  • Determinants of fetal testosterone concentrations remain largely unknown.

Purpose of the Study:

  • Investigate the relationship between fetal testosterone and maternal/fetal cortisol levels.
  • Explore sex-specific differences in these hormonal correlations.

Main Methods:

  • Analyzed blood samples from 44 human fetuses (15-38 weeks gestation) and paired maternal samples.
  • Measured fetal and maternal testosterone and cortisol concentrations.

Main Results:

  • Male fetuses exhibited higher testosterone levels than females.

Related Experiment Videos

  • Fetal testosterone positively correlated with fetal cortisol and maternal testosterone.
  • Maternal testosterone and fetal cortisol independently predicted fetal testosterone.

    • Conclusions:

    • In fetal development, a positive correlation exists between testosterone and cortisol.
    • This contrasts with adult physiology where cortisol often inhibits testosterone production.