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Updated: Aug 19, 2026

Asthma Detection Research Based on Voice Signal Processing and Machine Learning
Published on: July 22, 2025
Towards improving the accuracy of diagnosing asthma in early childhood
Hubert Schönberger1, Onno van Schayck, Jean Muris
1Department of General Practice, Caphri Research Institute, Maastricht, the Netherlands. huub.schonberger@hag.unimaas.nl
Insights
Diagnosing childhood asthma early is crucial. Combining wheezing history, family history of asthma, and atopic conditions aids general practitioners in accurate early asthma diagnosis in children.
Area of Science:
- Pediatric respiratory medicine
- General practice epidemiology
- Clinical diagnostics
Background:
- Accurate early asthma diagnosis in children is vital for appropriate treatment.
- Wheezing illnesses in early childhood present diagnostic challenges for general practitioners.
- Under- and over-diagnosis of asthma in young children is a recognized issue.
Purpose of the Study:
- To evaluate the utility of combining wheezing patterns, age of onset, respiratory/atopic morbidity, and sociodemographic factors for early asthma diagnosis in children.
- To assist general practitioners in making timely and precise asthma diagnoses.
Main Methods:
- A 20-year prospective birth cohort study in general practice.
- Analysis of adolescent asthma in relation to early childhood wheezing, respiratory conditions, atopic history, and sociodemographic data.
- Data sourced from the Continuous Morbidity Registration of the University of Nijmegen.
Main Results:
- Adolescent asthma was diagnosed in 6.4% of the cohort.
- Recurrent wheezing in early childhood (0-3 years) and wheezing at 4-6 years significantly increased asthma risk.
- Family history of asthma, atopic dermatitis, and sinusitis were independent risk factors, while later birth order and lower socioeconomic status were protective.
Conclusions:
- Easily accessible historical and clinical data can significantly aid in the early diagnosis of asthma in children presenting with wheezing.
- The study provides a framework for general practitioners to improve early asthma detection in pediatric patients.
Objectives:
Early and correct diagnosis of asthma in wheezing children is essential for early treatment and prevention of under- or over-treatment. The aim was to study whether combining frequency and age of onset of wheezing illness with respiratory and atopic morbidity at age 0-6 years and sociodemographic parameters for asthma might be helpful for the general practitioner to diagnose asthma early and accurately.
Methods:
Birth cohort, mean follow-up 20 years (SD 4.8) in general practice. The outcome, adolescent asthma, was analysed in relation to wheezing and non-wheezing respiratory and personal and familial atopic morbidity. All diagnoses were from the Continuous Morbidity Registration of the Department of General Practice of the University of Nijmegen, the Netherlands.
Results:
1586 (64%) of the children could be followed. Adolescent asthma occurred in 6.4%. There were indications for under- and over-diagnosis of asthma at age 0-6 years. Non-recurrent wheezing (only one episode) and recurrent wheezing (>or =2 episodes) in the first three years of life, and recurrent wheezing at age 4-6 increased the risk with odds ratios (95% confidence interval) of 3.3 (1.9-5.6), 4.7 (2.8-8.2) and 15.4 (7.1-33.7), respectively. The risk additionally increased independently with a family history for asthma, (2.0 [1.1-3.6]), atopic dermatitis (1.7 [1.1-2.7]) and sinusitis (2.9 [1.3-6.4]) and decreased for > or =2nd born children (0.38 [0.19-0.47]) and those with a low social-economic status (0.61 [0.39-0.94]).
Conclusion:
Easily available history and clinical data may facilitate the early diagnosis of asthma in children with wheezing illness.
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