Related Experiment Video
Updated: Aug 19, 2026

Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development
Published on: March 17, 2023
[Effects of Epimedium pubescens icariine on proliferation and differentiation of human osteoblasts]
Xiao-xue Yin1, Zhong-qiang Chen, Geng-ting Dang
1Third Hospital of Peking University, Beijing 100083, China. yxx2733_cn@sina.com
Objective:
To study the effects of epimedium pubescens icariine on the proliferation and differentiation of human osteoblasts.
Method:
Human osteoblasts were obtained by inducting human marrow mesenchymal stem cells (hMSCs) directionally. MTT was used to observe the proliferation and activity of ALP was assayed to observe the differentiation of the third passage human osteoblasts cultured in vitro. The expression of BMP-2 mRNA was checked by RT-PCR.
Result:
Epimedium pubescens icariine at the dose of 20 microg x mL(-1) increased greatly the proliferation and differentiation of human osteoblasts and promoted the expression of BMP-2 mRNA.
Conclusion:
Epimedium pubescens icariine enhances significantly the proliferation and differentiation of human osteoblasts, which may be mediated by increasing the expression of BMP-2 mRNA.
Related Concept Videos
Clinical Applications of Epidermal Stem Cells
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Renewal of Skin Epidermal Stem Cells

