Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Obesity and cardiac failure].

M Galinier1, A Pathak, J Roncalli

  • 1Fédération des services de cardiologie des hôpitaux de Toulouse, Unité INSERM U 317, CHU Rangueil. galinier.m@chu-toulouse.fr

Archives Des Maladies Du Coeur Et Des Vaisseaux
|February 24, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Test of CP Symmetry in the Neutral Decays of Λ via J/ψ→ΛΛ[over ¯].

Physical review letters·2026
Same author

Precise Measurement of the Chromoelectric Dipole Moment of the Charm Quark.

Physical review letters·2026
Same author

Precise Measurement of Matter-Antimatter Asymmetry with Entangled Hyperon-Antihyperon Pairs.

Physical review letters·2026
Same author

Search for Light Pseudoscalar Bosons, Pair-Produced in Higgs Boson Decays in the Four-Electron Final State in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

First Evidence for Mixing-Induced CP Violation in B_{s}^{0}→J/ψϕ(1020) Decays in pp Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

Observation of Λ[over ¯]p→K^{+}π^{+}π^{-}π^{0} and Λ[over ¯]p→K^{+}π^{+}π^{-}2π^{0}.

Physical review letters·2026

Obesity significantly increases cardiac failure risk, particularly diastolic dysfunction, due to complex physiopathological mechanisms. Weight loss can improve outcomes in obesity-related cardiomyopathy.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Physiopathology

Context:

  • Obesity is a growing public health concern in the US, contributing significantly to cardiac failure.
  • Studies indicate a direct correlation between increased body mass index and elevated cardiac failure risk.
  • Obesity is projected to become a leading cause of cardiac failure in the coming years.

Purpose:

  • To elucidate the physiopathological mechanisms linking obesity to left ventricular dysfunction.
  • To explore the hormonal and hemodynamic alterations induced by obesity in the myocardium.
  • To differentiate the forms of cardiac failure observed in obese patients and discuss diagnostic challenges.

Summary:

  • Obesity adversely affects left ventricular function through increased preload, afterload, and direct myocardial changes.

Related Experiment Videos

  • Mechanisms include hormonal secretions from adipocytes (e.g., angiotensin II, leptin) and genetic expression modifications.
  • Obesity is a primary cause of diastolic dysfunction (cardiac failure with preserved ejection fraction) and can lead to systolic dysfunction via cardiomyopathy or coronary artery disease.

    • Impact:

    • Understanding these mechanisms is crucial for managing cardiac failure in obese populations.
    • Obesity presents unique diagnostic challenges in cardiac failure assessment.
    • While obesity may improve survival in some cardiac failure patients by counteracting cachexia, it increases sudden death risk; weight loss can improve cardiac function and remodeling.