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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...

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Adult Zebrafish Injury Models to Study the Effects of Prednisolone in Regenerating Bone Tissue
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[Corticosteroid-induced osteoporosis].

Andrea Trombetti1, Pietra Pennisi, René Rizzoli

  • 1Service des maladies osseuses (Centre collaborateur de l'OMS pour la prévention de l'ostéoporose), département de réhabilitation et gériatrie, hôpitaux universitaires de Genève, 1211 Genève 14, Suisse. Andrea.Trombetti@hcuge.ch

La Revue Du Praticien
|February 24, 2005
PubMed
Summary
This summary is machine-generated.

Corticosteroid therapy frequently causes osteoporosis and fractures by decreasing bone formation and increasing resorption. Biphosphonates are a first-choice therapy for preventing this condition, as they increase bone density and reduce fracture rates.

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Area of Science:

  • Endocrinology
  • Bone Biology
  • Pharmacology

Context:

  • Corticosteroid therapy is widely used but leads to significant bone loss.
  • Osteoporosis and fractures are common adverse effects of corticosteroid treatment.
  • Cancellous bone is particularly vulnerable, showing reduced formation and increased resorption.

Purpose:

  • To review the prevention strategies for corticosteroid-induced osteoporosis.
  • To highlight the efficacy of biphosphonates in managing this condition.

Summary:

  • General measures include calcium, vitamin D, protein, and exercise.
  • Specific therapies, such as biphosphonates, are crucial.
  • Biphosphonates inhibit bone resorption, increase bone mineral density, and decrease vertebral fracture rates.

Impact:

  • Biphosphonates are recommended as a first-line treatment for preventing corticosteroid-induced osteoporosis.
  • Effective management can reduce the incidence of debilitating fractures in patients on long-term corticosteroid therapy.