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Updated: Aug 19, 2026
Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
Published on: May 24, 2021
[Assessment of ejection fraction by cardiovascular magnetic resonance in comparison with 99mTc gated SPECT]
Mieczysław Pasowicz1, Piotr Klimeczek, Ewa Wicher-Muniak
1Ośrodek Diagnostyki i Rehabilitacji, Chorób Serca i Płuc w Krakowskim, Szpitalu Specjalistycznym im. Jana Pawła II. m.pasowicz@szpitaljp2.krakow.pl
Insights
Cardiovascular magnetic resonance (CMR) and 99mTc gated SPECT (GSPECT) provide comparable measurements of left ventricular ejection fraction (EF) in patients with ischaemic heart disease. Both non-invasive methods are valuable for assessing cardiac function.
Area of Science:
- Cardiology
- Medical Imaging
- Diagnostic Techniques
Background:
- Ischaemic heart disease frequently causes impaired left ventricular (LV) function and reduced ejection fraction (EF).
- Cardiovascular magnetic resonance (CMR) is a key non-invasive diagnostic tool for assessing myocardial function.
- Assessing LV function is crucial in managing patients with cardiac conditions.
Purpose of the Study:
- To compare ejection fraction (EF) measurements between 99mTc gated SPECT (GSPECT) and CMR.
- To evaluate the diagnostic accuracy of CMR for assessing left ventricular systolic function.
Main Methods:
- The study included 35 patients (11 female, 24 male; mean age 57) post-myocardial infarction.
- Left ventricular ejection fraction (EF) was calculated using cine gradient echo sequences in CMR.
- EF was also measured using 99mTc gated SPECT (GSPECT).
Main Results:
- Mean EF measured by GSPECT was 50.5% +/- 17%.
- Mean EF measured by CMR was 48.3% +/- 15%.
- The difference in mean EF values between GSPECT and CMR was not statistically significant.
Conclusions:
- CMR measurements of EF demonstrated high concordance with GSPECT.
- While CMR-derived EF was slightly lower in most patients, the difference was not statistically significant.
- CMR is a precise, reproducible, and simple method for monitoring LV systolic function and serves as a valuable non-invasive cardiac diagnostic technique.
Background:
Impaired left ventricular (LV) function with decreased ejection fraction (EF) is a frequent finding in patients with ischaemic heart disease. As a non-invasive method, cardiovascular magnetic resonance (CMR) has become an important diagnostic method in cardiology within the past decade, especially for assessing myocardial function.
Aim:
The purpose of this study is to compare EF estimated with 99mTc gated SPECT (GSPECT) and with CMR.
Methods:
The study was performed in a group of 35 patients (11 F, 24 M; mean age 57 SD 10) after myocardial infarction. EF in CMR procedure was calculated using cine gradient echo sequences. GSPECT measured EF was estimated by Tc 99.
Results:
The mean value of EF measured with scintigraphy was 50.5 +/- 17%, and measured with CMR 48.3 +/- 15%. The difference in mean values of EF was not statistically significant.
Conclusions:
1. EF in CMR was highly concordant with GSPECT. 2. The mean value of EF measured with CMR in 75% of study patients was smaller than in the scintigraphy group, but the difference was not statistically significant. 3. CMR is a simple, precise and reproducible diagnostic method for monitoring left ventricle systolic function, and which is an additional non-invasive imaging technique in cardiac diagnosis.
