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Related Experiment Videos

Insemination data on men with varicoceles.

J L Marmar1, S L Corson, F R Batzer

  • 1Division of Urology, Cooper Hospital/University Medical Center, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Camden.

Fertility and Sterility
|May 1, 1992
PubMed
Summary
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The pathophysiology of varicoceles in the light of current molecular and genetic information.

Human reproduction update·2001

Sperm processing and intrauterine insemination (IUI) show potential benefits for selected men with a history of varicocele who have struggled to conceive naturally. This infertility treatment was effective in cases with normal sperm penetration assays.

Area of Science:

  • Reproductive Medicine
  • Andrology
  • Infertility Treatment

Background:

  • Varicocele is a common cause of male infertility.
  • Men with varicoceles often experience impaired sperm function.
  • Natural conception can be challenging for couples affected by male factor infertility.

Purpose of the Study:

  • To evaluate the efficacy of sperm processing and intrauterine insemination (IUI) in men with a history of varicocele.
  • To identify patient subgroups who may benefit from assisted reproductive technologies.
  • To assess pregnancy and fecundity rates in infertile couples with male varicocele.

Main Methods:

  • Retrospective analysis of 71 infertile couples.
  • Patients included men with varicocele history, categorized by semen analysis and sperm penetration assays (SPAs).

Related Experiment Videos

  • Intrauterine insemination (IUI) was performed after sperm processing, with varicocelectomy and medical treatments administered as indicated.

    • Main Results:

    • Six pregnancies occurred in 66 cycles of sperm processing and IUI among 28 men with normal SPAs, yielding a pregnancy rate (PR) of 21% and a fecundity rate of 0.09.
    • No pregnancies were achieved in 121 cycles among 43 men with abnormal SPA results or suboptimal semen parameters.
    • These findings suggest a differential response to IUI based on sperm function tests.

    Conclusions:

    • Sperm processing and IUI can be a beneficial infertility treatment for carefully selected men with varicoceles.
    • Patients with normal sperm penetration assays (SPAs) demonstrate a higher likelihood of success with IUI.
    • This approach offers a potential solution for couples facing infertility due to varicocele-associated male factor.