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Published on: November 4, 2010
Asthma management issues in infancy and childhood
1Department 4 Medical Research, Chang Gung Children's Hospital at Kaohsiung, 123 Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan. yangkd@adm.cgmh.org.tw
Treatments in Respiratory Medicine
|February 24, 2005
Summary
Childhood asthma prevalence is rising globally. Early prevention strategies targeting prenatal and early-life environmental exposures, alongside advances in personalized medicine, show promise for reducing asthma incidence and improving management in young children.
Area of Science:
- Pediatrics
- Allergology
- Environmental Health
Background:
- Childhood asthma prevalence has increased globally over the last two decades.
- Extrinsic asthma is predominant in children, with geographic variations in allergen sensitization.
- Established management guidelines exist for children over five, but treatment for those under five remains inconclusive.
Purpose of the Study:
- To review current understanding of childhood asthma prevalence, risk factors, and management strategies.
- To highlight the role of genetic susceptibility and environmental factors in asthma development.
- To explore potential future directions for prevention and individualized treatment in young children.
Main Methods:
- Review of global prevalence data, including the International Study of Asthma and Allergies in Children (ISAAC).
- Analysis of genetic and environmental risk factors associated with allergic sensitization.
- Examination of current and emerging management and prevention strategies for childhood asthma.
Main Results:
- Geographic variations in childhood asthma prevalence correlate with specific allergen sensitivities.
- Prenatal and early-life environmental exposures are critical in promoting allergic sensitization.
- Pharmacogenetics and pharmacogenomics offer potential for tailored early interventions.
Conclusions:
- Integrated approaches combining genetic insights and environmental controls are crucial for preventing childhood asthma.
- Further research is needed to refine management strategies for children under five.
- Personalized medicine holds promise for modulating airway remodeling and preventing asthma development.
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