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Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Junctional epidermolysis bullosa in two domestic shorthair kittens
Zeineb Alhaidari1, Thierry Olivry, Anne Spadafora
1Clinique Vétérinaire, Cidex 248, RN 85, 06330 Roquefort les Pins, France. z.alhaidari@wanadoo.ft
Veterinary Dermatology
|February 24, 2005
Abstract:
This article describes two cases of junctional epidermolysis bullosa in nonrelated kittens. Both cats exhibited pinnal erosions, oral ulcerations and severe onychomadesis. Histopathology, electron microscopy and/or indirect immunoperoxidase revealed subepidermal clefting, with the lamina densa remaining attached to the floor of the vesicles. Indirect immunofluorescence revealed reduced staining for laminin-5 gamma2 subunit in case 1 and beta3 subunit in case 2.

