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Multiple dermatofibromas associated with lupus profundus.

I Chan1, A Robson, J E Mellerio

  • 1Genetic Skin Disease Group, St John's Institute of Dermatology, St Thomas' Hospital, London, UK. ien.chan@kcl.ac.uk

Clinical and Experimental Dermatology
|February 24, 2005
PubMed
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Multiple dermatofibromas, rare skin growths, were observed in a patient with lupus profundus. This case highlights a potential link between autoimmune conditions and the development of numerous dermatofibromas.

Area of Science:

  • Dermatology
  • Immunology
  • Pathology

Background:

  • Multiple dermatofibromas are uncommon and often associated with systemic diseases like lupus erythematosus or HIV.
  • The pathogenesis of dermatofibromas remains largely unknown, though immune system alterations are suspected.
  • Lupus profundus is a rare form of lupus erythematosus affecting subcutaneous tissue.

Observation:

  • A 58-year-old woman presented with over 20 spontaneous dermatofibromas on her trunk and limbs.
  • She also had lipoatrophy and inflammatory subcutaneous nodules histologically confirmed as lupus profundus.
  • Systemic lupus erythematosus markers were absent, aside from mild arthritis.

Findings:

  • This case represents the first documented instance of multiple dermatofibromas associated with lupus profundus.

Related Experiment Videos

  • The association suggests a potential link between autoimmune diseases and the development of multiple dermatofibromas.
  • The patient was otherwise systemically well, indicating a localized autoimmune manifestation.

    • Implications:

    • This finding expands the known spectrum of conditions associated with multiple dermatofibromas.
    • Further research into this association may elucidate the unknown pathogenesis of dermatofibromas.
    • Recognizing this link could aid in diagnosing underlying autoimmune conditions in patients with multiple dermatofibromas.