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Updated: Jul 11, 2026

Examination of the Telomere G-overhang Structure in Trypanosoma brucei
Published on: January 27, 2011
Spliced leader RNA sequences of Trypanosoma rangeli are organized within the 5S rRNA-encoding genes
S Aksoy1, G L Shay, M S Villanueva
1Yale-MacArthur Center for Molecular Parasitology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.
Abstract:
The spliced leader RNA(SL RNA)-encoding genes of the salivarian New World trypanosome, Trypanosoma rangeli, are organized within the 5S rRNA tandem repeats. Each repeat contains genes encoding an SL RNA and a 5S rRNA in the same orientation of transcription. This SL-5S organization is also present in the African trypanosome, Trypanosoma vivax. A similar association of SL and 5S genes has been observed in some nematodes, but has not been described previously in trypanosomatids.
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