Synthesis, structure-activity relationship of some new anti-arrhythmic 5-arylidene imidazolidine-2,4-dione derivatives
Related Experiment Video
Updated: Aug 19, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Elzbieta Pekala1, Katarzyna Stadnicka, Agnieszka Broda
1Department of Chemical Technology and Biotechnology of Drugs, Jagiellonian University Medical College, ul. Medyczna 9, 30-688 Kraków, Poland.
Abstract:
The synthesis of unsubstituted and halogen substituted 5-arylidene basic amide derivatives of imidazolidine-2,4-dione is described. Structural elucidation based on X-ray analysis was performed for four representative compounds. The effect of the studied compounds on the electrocardiogram was examined in vitro in the non-working heart perfusion test and that of an anti-arrhythmic activity in the rat coronary artery ligation-reperfusion model. The most active compound: (5Z)-(3-chloro)benzylidene-3-{2-[4-(hydroxyethyl)piperazin-1-yl]-2-oxoethyl}imidazolidine-2,4-dione has shown properties of the compounds belonging to class Ia, according to the Vaughan Williams classification. Chosen compounds evaluated in vivo were devoid of anticonvulsant and neurotoxical activity.
Related Concept Videos
Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...
Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship
