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Particle size distribution and evolution in tablet structure during and after compaction.

Frauke Fichtner1, Ake Rasmuson, Göran Alderborn

  • 1Department of Pharmacy, Uppsala University, Box 580, SE-751 23 Uppsala, Sweden.

International Journal of Pharmaceutics
|February 24, 2005
PubMed
Summary

Particle size distribution significantly impacts tablet strength post-compaction, but not tablet porosity during compression. This effect is complex, influenced by instability mechanisms and lubricant presence.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Tablet properties like porosity and tensile strength are crucial for drug efficacy and stability.
  • Particle size distribution is a key factor in powder formulation, potentially influencing tablet characteristics.

Purpose of the Study:

  • To investigate how particle size distribution affects tablet structure and strength evolution.
  • To determine the influence of particle size spread on tablet porosity and tensile strength post-compaction.

Main Methods:

  • Prepared powders (sucrose, sodium chloride, paracetamol) with varying particle size distributions.
  • Formed tablets and measured porosity and tensile strength immediately after compaction and after storage.
  • Assessed the impact of lubricant (magnesium stearate) on tablet tensile strength.

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Main Results:

  • Particle size distribution did not affect tablet porosity or tensile strength during compression.
  • A significant, complex influence of particle size spread was observed on the post-compaction increase in tablet tensile strength.
  • This influence was linked to the instability mechanism and the presence of lubricant.

Conclusions:

  • Particle size distribution is not critical for tablet porosity.
  • The spread in particle size can significantly affect tablet tensile strength through post-compaction reactions.