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Related Experiment Videos

Ziprasidone-induced galactorrhea: a case report.

Miloslav Kopecek1, Martin Bares, Pavel Mohr

  • 1Psychiatric Centre Prague, Czech Republic. kopecek@pcp.lf3.cuni.cz

Neuro Endocrinology Letters
|February 24, 2005
PubMed
Summary
This summary is machine-generated.

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Second-generation antipsychotics like ziprasidone can cause side effects, including galactorrhea, due to dopamine D2 receptor blockade. This highlights the need for awareness among psychiatrists regarding potential adverse reactions.

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Second-generation antipsychotics were developed to have fewer side effects than conventional antipsychotics.
  • Ziprasidone is a second-generation antipsychotic used in treating psychiatric disorders.

Observation:

  • A patient with recurrent depressive disorder experienced galactorrhea after nine days of ziprasidone treatment.
  • Galactorrhea persisted for 36 days, with elevated prolactin levels (28 ng/ml).

Findings:

  • Ziprasidone treatment was associated with hyperprolactinemia, indicated by galactorrhea and elevated prolactin levels.
  • Thyroid function and lithium levels remained normal during ziprasidone therapy.
  • Discontinuation of ziprasidone led to the resolution of galactorrhea and normalization of prolactin levels (18 ng/ml).

Related Experiment Videos

Implications:

  • Even second-generation antipsychotics can cause side effects related to dopamine D2 receptor blockade.
  • Psychiatrists must be vigilant about potential adverse effects like galactorrhea with ziprasidone.
  • This case underscores the importance of monitoring for hyperprolactinemia in patients treated with ziprasidone.