Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

TLR2 Arg677Trp polymorphism in leprosy: revisited.

Dheeraj Malhotra1, Vineet Relhan, B S N Reddy

  • 1National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.

Human Genetics
|February 24, 2005
PubMed
Summary

The Toll-like receptor 2 (TLR2) Arg677Trp polymorphism, previously linked to leprosy, is not a true genetic variation. This finding clarifies the genetic basis of leprosy and TLR2 function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Study on clinical types of warts and its correlation with human papillomavirus genotypes.

Indian journal of sexually transmitted diseases and AIDS·2026
Same author

Detailing by Videodermoscopy - A Delight in the Trichological Diagnosis.

International journal of trichology·2025
Same author

Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals key associations with AD pathology.

Nature communications·2025
Same author

Apixaban-Induced Cutaneous Small Vessel Vasculitis.

Indian journal of dermatology·2025
Same author

Melatonin in Dermatology.

Indian dermatology online journal·2025
Same author

Trichoscopic Evolution of Alopecia Areata: An Algorithmic Approach.

International journal of trichology·2025

Area of Science:

  • Immunogenetics
  • Microbiology
  • Dermatology

Background:

  • Leprosy is a chronic infectious disease primarily affecting the skin and peripheral nerves.
  • Toll-like receptor 2 (TLR2) plays a crucial role in the innate immune response to mycobacterial infections, including leprosy.
  • A specific TLR2 polymorphism (Arg677Trp) was previously associated with lepromatous leprosy in Koreans.

Purpose of the Study:

  • To investigate the Arg677Trp polymorphism in the Toll-like receptor 2 (TLR2) gene in an Indian leprosy patient cohort.
  • To determine if variations in the TLR2 promoter region contribute to leprosy susceptibility.
  • To clarify the genetic basis of TLR2-mediated immune responses in leprosy.

Main Methods:

  • Case-control study involving 286 Indian leprosy patients and 183 controls.

Related Experiment Videos

  • Genotyping of the TLR2 Arg677Trp polymorphism using direct PCR sequencing.
  • Analysis of potential variations in the TLR2 gene promoter region.

    • Main Results:

    • The TLR2 Arg677Trp variant, previously linked to lepromatous leprosy, was found not to be a true polymorphism.
    • The observed variation originated from a homologous duplicated region of TLR2 exon 3, located upstream.
    • No significant association was found between this variant and leprosy in the Indian population.

    Conclusions:

    • The Arg677Trp variant is an artifact arising from a pseudogene or duplicated region, not a functional polymorphism.
    • This finding refutes the association of this specific TLR2 variant with leprosy susceptibility.
    • Re-evaluation of genetic associations with TLR2 in leprosy is warranted, considering potential pseudogene interference.