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Sickle cell vaso-occlusive crisis induces the release of circulating serum heat shock protein-70
Adeboye H Adewoye1, Elizabeth S Klings, Harrison W Farber
1Center for Excellence in Sickle Cell Disease, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Abstract:
Inflammation may play an important role in the pathophysiology of sickle cell disease (SCD), and recent studies have identified the 70-kDa heat shock protein (Hsp70) as an important mediator of inflammatory responses. Here we demonstrate a significant increase in circulating serum Hsp70 level in SCD during vaso-occlusive crisis (VOC) as compared with baseline steady-state levels (P <0.05) and a significant increase in Hsp70 levels in SCD at baseline compared with normal controls (P <0.05). Taken together, these results indicate that circulating serum Hsp70 might be a marker for VOC in SCD.
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