Related Experiment Video
Updated: Aug 16, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
[Study on genetic polymorphism of NQO1 and susceptibility to benzene poisoning]
Yan Chen1, Zhiying Ji, Jianning Xu
1Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Objective:
To explore the relationship between genetic polymorphism of NQO1 and susceptibility to benzene poisoning (BP).
Methods:
The genetic polymorphism of NQO1 for 100 patients with benzene poisoning and 90 workers exposed to benzene who were engaged in the same working time and job title as patients with benzene poisoning were detected by PCR-RFLP.
Results:
There was a 2.82-fold (95% CI: 1.42-5.58 ) increased risk of BP in the subjects with NQO1 C609T mutation genotype (T/T) compared with those carrying heterozygous (C/T) and wild type (C/C), and there was a 2.94-fold (95% CI: 1.25-6.90) increased risk of BP in the subjects with NQO1 C609T mutation genotype (T/T) compared with those carrying wild type (C/C) . There was a trend that the risk of BP in subjects with NQO1 C609T mutation genotype (T/T) was higher than those carrying heterozygous (C/T) and even higher than those carrying wild type (C/C) (chi2(trend) = 6.01, P = 0.014).
Conclusion:
The subjects with NQO1 C609T mutation genotype (T/T) were more susceptive to benzene and NQO1 is as a biomarker to assessment the risk of benzene poisoning for individual.
Related Concept Videos
Physical Properties of Amines
NMR Spectroscopy of Benzene Derivatives
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

