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[Caco-2 cell monolayers and it's application in toxicological research]

Zhiwei Liu1, Bingheng Chen

  • 1School of Public Health, Fudan University, Shanghai 200032, China.

Wei Sheng Yan Jiu = Journal of Hygiene Research
|February 25, 2005
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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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