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[Tolerable upper intake level on vitamins and minerals].

Jianlie Zhou1, Xiaoshu Chen

  • 1Wyeth Consumer Healthcare, Shanghai 200041, China.

Wei Sheng Yan Jiu = Journal of Hygiene Research
|February 25, 2005
PubMed
Summary

This review examines the scientific basis for Tolerable Upper Intake Levels (ULs) for vitamins and minerals. It compares ULs between China and the US, introducing new concepts for specific nutrients.

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Area of Science:

  • Nutritional Science
  • Toxicology
  • Public Health

Background:

  • Safety assessments of vitamin and mineral intake are crucial for public health.
  • Existing frameworks for establishing Tolerable Upper Intake Levels (ULs) exist in the US, UK, and Europe.
  • International comparisons of nutrient ULs are needed to ensure consistent safety standards.

Purpose of the Study:

  • To review the scientific rationale behind establishing ULs, including risk assessment and uncertainty factors.
  • To compare established ULs for key vitamins and minerals between China and the United States.
  • To introduce novel concepts for ULs concerning specific micronutrients: Vitamin A, D, Calcium, Copper, Iodine, Phosphorus, Selenium, Iron, and Vanadium.

Main Methods:

  • Literature review of safety assessments from authoritative bodies (US FNB, UK MAFF, European SCF).
  • Comparative analysis of UL values for selected vitamins and minerals in Chinese and American dietary guidelines.
  • Synthesis of emerging scientific concepts related to nutrient ULs.

Main Results:

  • The rationale for ULs involves assessing adverse effects, dosage-response relationships, and applying uncertainty factors.
  • Significant differences in ULs for several vitamins and minerals were observed between Chinese and American recommendations.
  • New conceptual approaches for setting ULs for Vitamin A, D, Ca, Cu, I, P, Se, Fe, and V are proposed.

Conclusions:

  • Understanding the scientific basis of ULs is essential for dietary guidance.
  • International harmonization of ULs requires addressing discrepancies in methodologies and data.
  • The proposed new concepts may refine future UL setting for specific micronutrients, enhancing nutritional safety.

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