Multinucleated myogenic giant cell formation: an unusual cellular reaction in acute myocardial infarction

We describe the presence of multinucleated myogenic giant cells in the heart of a patient with acute myocardial infarction. This represents an unusual myocardial cellular reaction, reminiscent of skeletal muscular regeneration following injury. The features that allow its differentiation from idiopathic giant cell myocarditis are discussed.