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Updated: Aug 19, 2026

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing
Published on: December 23, 2022
Evolutionary origins and sequence of the Escherichia coli O4 O-antigen gene cluster
Jocelyne M D'Souza1, Gabrielle N Samuel, Peter R Reeves
1School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia.
Abstract:
Escherichia coli express many types of O antigen, present in the outer membrane of the Gram-negative bacterial cell wall. O-Antigen biosynthesis genes are clustered together and differences seen in O-antigen types are due to genetic variation within this gene cluster. Sequencing of the E. coli O4 O-antigen gene cluster revealed a similar gene order and high levels of similarity to that of E. coli O26; indicating a common ancestor. These lateral transfer events observed within O-antigen gene clusters may occur as part of the evolution of the pathogenic clones.
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