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Related Experiment Videos

Antidepressant-induced sweating.

Todd R Marcy1, Mark L Britton

  • 1Department of Pharmacy: Clinical and Administrative Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117-1223, USA. todd-marcy@ouhsc.edu

The Annals of Pharmacotherapy
|February 25, 2005
PubMed
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Excessive sweating can be a side effect of antidepressants like paroxetine. Management may involve dose reduction, switching medications, or using agents such as benztropine to control sweating.

Area of Science:

  • Pharmacology
  • Clinical Pharmacy
  • Neuroscience

Background:

  • Antidepressants, including selective serotonin-reuptake inhibitors (SSRIs), are widely prescribed for various mental health conditions.
  • Antidepressant-induced sweating is a recognized but often underreported adverse effect.
  • Understanding the mechanisms and management of this side effect is crucial for patient care.

Observation:

  • A case of excessive sweating, primarily on the head and neck, was reported in a 59-year-old female following paroxetine initiation.
  • Other potential causes of hyperhidrosis were excluded.
  • Sweating symptoms resolved within 5 weeks of discontinuing paroxetine, with a probable causal link established by the Naranjo scale.

Findings:

  • Excessive sweating is associated with various antidepressant classes, including SSRIs and venlafaxine.

Related Experiment Videos

  • Management strategies for antidepressant-induced sweating include dose reduction, medication substitution, or discontinuation.
  • Pharmacological interventions like benztropine or cyproheptadine can be effective in managing persistent sweating.

    • Implications:

    • A patient-specific approach is recommended for managing antidepressant-induced sweating.
    • Clinicians should consider non-pharmacological and pharmacological interventions based on individual patient needs and contraindications.
    • This case highlights the importance of recognizing and addressing medication-induced side effects to improve patient adherence and quality of life.