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Risperidone and breast-feeding.

W Aichhorn1, C Stuppaeck, A B Whitworth

  • 1Department of Psychiatry, University of Innsbruck, Innsbruck, Austria. wolfgang.aichhorn@uibk.ac.at

Journal of Psychopharmacology (Oxford, England)
|February 25, 2005
PubMed
Summary

Risperidone is a safe antipsychotic for breastfeeding mothers and infants. Drug levels in breast milk were low, with no adverse effects observed in the infant, indicating a favorable risk-benefit profile.

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Neonatal Medicine

Background:

  • Postpartum psychosis requires effective treatment.
  • Antipsychotic use during breastfeeding necessitates safety evaluation.

Observation:

  • A breastfeeding mother with acute postpartum psychosis was treated with risperidone.
  • Risperidone and its active metabolite, 9-hydroxyrisperidone, were measured in maternal serum, infant serum, and breast milk.

Findings:

  • Drug levels in breast milk were 10-fold lower than in maternal serum.
  • The mother showed a good response to risperidone treatment.
  • The infant exhibited normal psychomotor development without adverse effects.

Implications:

  • Risperidone appears to be a safe and effective treatment option for breastfeeding mothers with postpartum psychosis.
  • This case contributes to the understanding of antipsychotic pharmacokinetics during lactation.
  • Further research on antipsychotics in breastfeeding populations is warranted.

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