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Published on: July 6, 2013
Cytomegalovirus infection in a patient with Crohn's ileocolitis
Sahin Coban1, Arzu Ensari, Mehmet Ayhan Kuzu
1Department of Gastroenterology, Ankara University Medical School, Balgat 06540, Ankara, Turkey. scoban72@yahoo.com
Abstract:
Cytomegaloviral enterocolitis is an uncommon infection that can complicate inflammatory bowel disease. A case of a patient with a three-year history of Crohn's disease is reported. He had been in a stable condition on mesalamine 4 g/day and methylprednisolone 10 mg/day for three years until four weeks before admission. The patient was admitted with complaints of fever, abdominal pain and watery diarrhea. A diagnosis of an exacerbation of Crohn's disease was established. The radiological examination revealed narrowing of the terminal ileum. Multiple fistulas and abscess-like images were observed. The patient then underwent ileocolic resection and ileostomy. The histopathological examination revealed Crohn's ileocolitis with superimposed cytomegalovirus infection. In patients with rapidly deteriorating inflammatory bowel disease, cytomegalovirus infection should be kept in mind as one of the differential diagnoses.
Insights
Cytomegaloviral enterocolitis is a rare infection that can worsen inflammatory bowel disease. This case highlights the importance of considering cytomegalovirus infection in patients with severe Crohn's disease flares.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Pathology
Background:
- Cytomegaloviral enterocolitis is an infrequent complication of inflammatory bowel disease (IBD).
- Inflammatory bowel disease, including Crohn's disease, requires ongoing management to maintain remission.
Observation:
- A patient with a three-year history of Crohn's disease presented with acute symptoms of fever, abdominal pain, and watery diarrhea.
- Radiological findings indicated terminal ileum narrowing, fistulas, and abscesses, suggesting a severe Crohn's disease exacerbation.
Findings:
- Histopathological examination confirmed Crohn's ileocolitis with a superimposed cytomegalovirus (CMV) infection.
- The patient underwent ileocolic resection and ileostomy due to the severity of the condition.
Implications:
- Cytomegalovirus infection should be considered in the differential diagnosis for patients with rapidly deteriorating inflammatory bowel disease.
- Early recognition and management of CMV in IBD patients may prevent severe complications and surgical interventions.
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