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Published on: April 15, 2015
[The role of genetics in alcohol dependence]
Guilherme Peres Messas1, Homero Pinto Vallada Filho
1Unidade de Pesquisa em Alcool e Drogas, UNIFESP, Brazil. messas@netpoint.com.br
Abstract:
In this article we examined the heritability of alcohol dependence. A review of family, twin and adoption studies, allowed us to support the thesis of an important genetic component in this dependence. The transmission of this heritability occurs through a biological vulnerability associated to environmental factors, in a model called epigenetic. We also discussed the relationship between biological vulnerability and high-risk phenotypes for alcohol dependence. In the end, we briefly comment on the molecular genetic studies associated with this disorder.
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