Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optimal replication of poliovirus within cells.

Roland R Regoes1, Shane Crotty, Rustom Antia

  • 1Department of Biology, Emory University, Atlanta, Georgia 30322, USA. rregoes@emory.edu

The American Naturalist
|February 25, 2005
PubMed
Summary

This study models poliovirus replication, revealing resource competition explains growth saturation. Optimizing viral replication suggests a specific positive to negative strand ratio, offering evolutionary insights.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolution of Ivermectin Resistance in the Nematode Model <i>Caenorhabditis elegans</i>: Critical Influence of Population Size and Altered Emodepside Efficacy.

Evolutionary applications·2026
Same author

Quantifying the role of pre-existing tissue resident cellular immunity in limiting respiratory virus transmission.

PLoS pathogens·2026
Same author

The role of the innate immune system in shaping the dynamics of antimicrobial treatment.

bioRxiv : the preprint server for biology·2026
Same author

CD8+ T cells and Humoral Immunity Influence the Development of Antibody-Dependent Enhancement: Implications for Vaccine Design.

bioRxiv : the preprint server for biology·2026
Same author

Preventing Disease Emergence Following Eradication: Application to Mpox.

bioRxiv : the preprint server for biology·2026
Same author

What drives bacterial extinction? The role of bacteriophages.

Theoretical population biology·2025

Area of Science:

  • Virology
  • Mathematical Biology
  • Evolutionary Biology

Background:

  • Poliovirus is a prototypic RNA virus.
  • Viral replication dynamics often show saturation.
  • Understanding poliovirus replication is crucial for virology.

Purpose of the Study:

  • To construct a mathematical model for within-cell poliovirus replication.
  • To explain viral replication saturation using resource utilization.
  • To explore conditions optimizing poliovirus growth and its evolutionary implications.

Main Methods:

  • Developed an exponential growth model for viral genome copy number.
  • Incorporated resource utilization into the model to account for saturation.
  • Analyzed model parameters to predict optimal replication conditions.

Related Experiment Videos

Main Results:

  • Resource limitation explains the saturation of poliovirus replication dynamics.
  • Optimized poliovirus replication predicts a specific positive to negative strand RNA ratio.
  • The predicted ratio closely matches observed experimental data.

Conclusions:

  • Mathematical modeling provides insights into poliovirus replication strategies.
  • Resource competition is a key factor in viral growth dynamics.
  • Findings suggest poliovirus may have evolved optimized life-history traits for replication.