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Related Experiment Videos

[Thyrotoxic encephalopathy showing reversible diffusion-weighted imaging abnormalities].

Fujio Fujiki1, Yoshio Tsuboi, Nobuhiro Saito

  • 1Fifth Department of Internal Medicine, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

No to Shinkei = Brain and Nerve
|February 26, 2005
PubMed
Summary
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A case of thyrotoxic encephalopathy presented with fever and altered consciousness. High-dose corticosteroids and acyclovir led to rapid improvement, suggesting their efficacy in managing this rare neurological condition.

Area of Science:

  • Neurology
  • Endocrinology

Background:

  • Thyrotoxic encephalopathy is a rare neurological complication of hyperthyroidism.
  • It often presents with altered mental status and can mimic other neurological disorders.

Observation:

  • A 31-year-old male presented with acute fever and severe consciousness disturbance.
  • MRI revealed cytotoxic edema in the corpus callosum and cerebellum. EEG showed frontal fast wave abnormalities.
  • Cerebrospinal fluid analysis showed elevated opening pressure but was otherwise normal.

Findings:

  • The patient showed a dramatic improvement in consciousness and fever following treatment with high-dose dexamethasone and acyclovir.
  • Subsequent investigations confirmed hyperthyroidism with positive anti-thyroid stimulating hormone receptor antibodies.

Related Experiment Videos

  • Diffusion-weighted imaging (DWI) and EEG abnormalities resolved within ten days.

    • Implications:

    • This case highlights the potential benefit of corticosteroid therapy in thyrotoxic encephalopathy.
    • Early recognition and prompt treatment can lead to favorable neurological outcomes.
    • The findings underscore the importance of considering endocrine disorders in patients with unexplained neurological symptoms.