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Peripheral vascular disease and serum phosphorus in hemodialysis: a nested case-control study
1Epidemiology Unit and Brunner Institute of Medical Research, Holon, Israel. mboaz8@yahoo.com
Clinical Nephrology
|February 26, 2005
Summary
Elevated serum phosphorus (P) is a significant risk factor for peripheral vascular disease (PVD) in hemodialysis patients. This finding supports P and calcium x P (Ca x P) in PVD development.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Biochemistry
Background:
- Serum phosphorus (P) and calcium x P (Ca x P) are often high in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD).
- Elevated P and Ca x P levels are linked to vascular calcification in HD patients.
Purpose of the Study:
- To investigate serum P and Ca x P as risk factors for new peripheral vascular disease (PVD) in HD patients with existing cardiovascular disease (CVD).
Main Methods:
- A nested case-control study analyzed 11 incident PVD events from the SPACE trial cohort.
- PVD was clinically diagnosed and confirmed with ultrasound.
- Cases were matched with controls based on treatment group, age, and gender.
Main Results:
- PVD patients had significantly higher serum P and Ca x P levels than controls.
- Serum P was the sole significant predictor of PVD in univariate (OR 2.02) and multivariate (OR 2.4) analyses.
- Multivariate analysis adjusted for factors like diabetes, smoking, and medications.
Conclusions:
- The study findings suggest serum P and Ca x P play a role in the development of PVD in hemodialysis patients.
- These results support the involvement of P and Ca x P in the pathogenesis of PVD in this population.
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