Two new cytotoxic linderazulenes from a deep-sea gorgonian of the genus Paramuricea
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N Srinivasa Reddy1, John K Reed, Ross E Longley
1Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, FL 34946, USA.
Journal of Natural Products
|February 26, 2005
Abstract:
The known compound linderazulene (1) and two new linderazulenes (2, 3) were isolated from a deep-sea gorgonian Paramuricea sp. The structures of 2 and 3 were determined through spectroscopic methods. Compounds 1-3 show moderate in vitro cytotoxicity against the P388 murine leukemia cell line with IC(50)'s of 18.8, 2.7, and 15.6 microg/mL, respectively. Compound 2 showed moderate activity against the PANC-1 pancreatic cell line with an IC(50) of 18.7 microg/mL.

