Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cocaine Rapid Efficacy Screening Trials (CREST): lessons learned.

Kyle M Kampman1, Deborah Leiderman, Tyson Holmes

  • 1Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA. kampman_k@mail.trc.upenn.edu

Addiction (Abingdon, England)
|February 26, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intranasal Oxytocin for Alcohol Use Disorder: A Randomized, Double-Blind, Placebo-Controlled Multisite Trial Assessing Efficacy and Safety.

Alcohol, clinical & experimental research·2026
Same author

Perceptions of Buprenorphine With Naloxone Treatment and the Fear of Precipitated Withdrawal: A Qualitative Exploration With HIV Prevention Trials Network 094 INTEGRA Participants and Staff.

Drug and alcohol review·2026
Same author

Advancing Kratom Science and Regulation: A Comparative Framework With Cannabis.

Journal of addiction medicine·2026
Same author

Clavulanic Acid Attenuated Cocaine Craving in Individuals with Cocaine Use Disorder.

Psychopharmacology bulletin·2026
Same author

Safety of Intravenous Methamphetamine in Patients Taking Mirtazapine: A Two-Site Phase 1b Randomized Controlled Trial.

Journal of clinical psychopharmacology·2026
Same author

Integrating HIV and Stimulant-Use Disorder Treatment: A Pilot Implementation Effectiveness Trial of Contingency Management in HIV Care.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026

The Cocaine Rapid Efficacy Screening Trials (CREST) screened 18 medications for cocaine dependence treatment. Three medications showed promise, indicating the trials

Area of Science:

  • Clinical Pharmacology
  • Addiction Medicine
  • Psychopharmacology

Background:

  • The National Institute on Drug Abuse Division of Treatment Research and Development (NIDA, DT R&D) initiated the Cocaine Rapid Efficacy Screening Trials (CREST).
  • The CREST program aimed to accelerate the identification of effective medications for cocaine dependence.
  • Previous open-label trials often showed positive responses to medications, necessitating placebo-controlled designs.

Purpose of the Study:

  • To rapidly screen multiple medications for their efficacy in treating cocaine dependence.
  • To establish a standardized framework for medication screening in addiction research.
  • To identify promising candidates for further, larger-scale clinical trials.

Main Methods:

  • Seven distinct trials were conducted, involving 398 cocaine-dependent patients across four US sites.

Related Experiment Videos

  • Each trial compared several candidate medications against an unmatched placebo.
  • Standardized procedures and outcome measures were used to ensure comparability across trials.

    • Main Results:

    • Three of the 18 screened medications demonstrated sufficient promise for advancement to larger trials.
    • Development of common statistical procedures facilitated cross-site and temporal comparisons.
    • Pooled data analysis provided insights into cocaine dependence and its treatment.

    Conclusions:

    • The CREST trials effectively screened medications for cocaine dependence treatment.
    • The screening framework proved useful but requires design modifications for future application.
    • Further research should incorporate identified improvements to optimize the screening process.