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Hemorrhagic stroke in a child with protein S and factor VII deficiencies

Katherine Lietz1, Stephanie E Kuehling, Joan B Parkhurst

  • 1Department of Pediatric Hematology/Oncology, Oklahoma University Health Sciences Center, and Children's Hospital, 940 NE Thirteenth Street, Oklahoma City, OK 73104, USA.

Pediatric Neurology
|February 26, 2005
PubMed

Insights

A young male with a family history of protein S deficiency developed neurological symptoms and stroke due to combined protein S and factor VII deficiencies.

Area of Science:

  • Neurology
  • Hematology
  • Genetics

Background:

  • A 12-year-old male with a family history of protein S deficiency presented with neurological deficits.
  • The patient experienced a 10-day febrile illness preceding symptom onset.

Observation:

  • Clinical presentation included confusion, aphasia, and right upper extremity weakness.
  • Imaging revealed cerebral sinovenous thrombosis and a left parietal hemorrhagic stroke.

Findings:

  • Laboratory investigations identified deficiencies in both protein S and factor VII.
  • This dual deficiency likely contributed to the thrombotic and hemorrhagic events.

Implications:

  • Highlights the importance of considering combined coagulation factor deficiencies in pediatric thrombosis.
  • Suggests genetic screening for protein S and factor VII deficiencies in at-risk individuals.
  • Underscores the complex interplay between genetic predisposition and acquired factors in cerebrovascular events.

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