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Zoster-associated intracranial hypertension.
John J Millichap1, Jeremy L Freeman
1Departments of Pediatrics and Internal Medicine, Brody School of Medicine at East Carolina University, Greenville, NC, USA.
Pediatric Neurology
|February 26, 2005
Summary
Varicella-zoster virus reactivation caused serious neurological issues in a teen. This rare complication led to intracranial hypertension, successfully managed with lumbar punctures and acetazolamide.
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- Varicella-zoster virus (VZV) is known for causing chickenpox and shingles.
- VZV reactivation can lead to neurological complications, though rare.
Observation:
- A 14-year-old female presented with headache, vomiting, rash, and papilledema.
- Herpes zoster was diagnosed, and cerebrospinal fluid analysis showed pleocytosis and elevated protein.
- Varicella-zoster virus DNA was detected in cerebrospinal fluid via PCR.
Findings:
- The patient experienced intracranial hypertension secondary to VZV infection.
- Treatment involved repeated lumbar punctures and acetazolamide for managing elevated intracranial pressure.
Implications:
- This case highlights an unusual neurological complication of VZV reactivation.
- Early diagnosis and management are crucial for favorable outcomes in VZV-related neurological conditions.