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Related Experiment Videos

Developmental processes and the induction of cardiovascular function: conceptual aspects.

Mark A Hanson1, Peter D Gluckman

  • 1Centre for Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital Level F (887), Coxford Road, Southampton S016 5YA, UK. m.hanson@soton.ac.uk

The Journal of Physiology
|February 26, 2005
PubMed
Summary

The developmental origins of disease concept, influenced by maternal effects and environmental factors, impacts offspring cardiovascular health. Understanding these mechanisms is key for life-course disease prevention.

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Area of Science:

  • Developmental Biology
  • Epigenetics
  • Cardiovascular Disease Etiology

Background:

  • The developmental origins of disease concept is widely accepted.
  • Research is focused on elucidating the underlying mechanisms.
  • Maternal effects, where mothers influence offspring phenotypes, are a key phenomenon.

Purpose of the Study:

  • To explore the biological mechanisms behind the developmental origins of disease.
  • To synthesize experimental and clinical data for a life-course approach to cardiovascular disease prevention.
  • To emphasize the role of maternal effects and environmental factors.

Main Methods:

  • Review of existing experimental and clinical data.
  • Focus on animal models to study cardiovascular phenotypic attributes.

Related Experiment Videos

  • Analysis of pre- and postnatal environmental transitions, including nutrition and energy expenditure.

    • Main Results:

    • Maternal effects can induce phenotypic changes in offspring, resembling human cardiovascular pathologies.
    • The timing of environmental cues and maternal diet significantly impact offspring development.
    • Epigenetic mechanisms are implicated in mediating these developmental effects.

    Conclusions:

    • A conceptual framework is provided for integrating diverse data on developmental origins.
    • Understanding these mechanisms is crucial for a life-course perspective on cardiovascular disease prevention.
    • Maternal nutrition and environmental exposures during development are critical determinants of long-term health.