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Naltrexone for alcohol-dependent patients.

J Ahmadi1, M Babaeebeigi, I Maany

  • 1Shiraz University of Medical Sciences, Shiraz, Fars Province, Iran. jamshid-ahmadi@yahoo.com

Irish Journal of Medical Science
|March 1, 2005
PubMed
Summary

Naltrexone 50 mg/day significantly improved treatment retention for alcohol-dependent patients compared to placebo. This medication aids in maintaining individuals in outpatient treatment programs.

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Area of Science:

  • Addiction Medicine
  • Psychopharmacology
  • Clinical Psychiatry

Background:

  • Naltrexone at 50 mg/day is known to reduce alcohol consumption and relapse rates.
  • Alcohol dependence is a significant public health concern requiring effective treatment strategies.

Purpose of the Study:

  • To evaluate the efficacy of 50 mg/day naltrexone in maintaining alcohol-dependent patients in a 36-week outpatient treatment program.
  • To assess the impact of naltrexone on treatment retention rates.

Main Methods:

  • A randomized controlled trial involving 116 male alcohol-dependent patients meeting DSM-IV criteria.
  • Participants received either 50 mg/day naltrexone or a placebo, alongside weekly individual counseling sessions.
  • Treatment retention, measured by days retained in treatment, was the primary outcome.

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Main Results:

  • A significantly higher completion rate was observed in the naltrexone group (44.8%) compared to the placebo group (25.9%).
  • The difference in completion rates was statistically significant (chi2=4.56, p=0.033).

Conclusions:

  • Naltrexone 50 mg/day demonstrates efficacy in improving treatment retention for alcohol-dependent individuals in an outpatient setting.
  • The findings support the use of naltrexone as a safe and effective adjunct therapy for alcohol dependence treatment in Iran.