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The effect of basic fibroblast growth factor on delayed-replanted monkey teeth.

Varawan Sae-Lim¹, Wei Yi Ong, Zhimei Li

¹Department of Restorative Dentistry, Faculty of Dentistry, National University of Singapore, Republic of Singapore. rsdvsl@nus.edu.sg

Journal of Periodontology

|March 1, 2005

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Basic fibroblast growth factor (bFGF) with fibrin glue showed a slight, though not statistically significant, increase in complete healing for delayed-replanted monkey teeth, suggesting potential for future research in regenerative dentistry.

Area of Science:

Dental research
Regenerative medicine
Histology

Background:

Basic fibroblast growth factor (bFGF) aids wound healing and periodontal regeneration.
bFGF's efficacy on delayed-replanted teeth prone to resorption requires investigation.

Purpose of the Study:

To histologically evaluate topical bFGF with or without fibrin glue on delayed-replanted monkey teeth.
To assess the impact on replacement resorption and healing outcomes.

Main Methods:

Endodontically treated monkey teeth underwent delayed replantation after 1-hour drying.
Experimental groups received topical bFGF with or without fibrin glue.
Histological analysis after 12 weeks evaluated complete vs. unfavorable healing.

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Main Results:

Negative controls (immediate replantation) showed significantly higher complete healing (98.88%).
The bFGF/fibrin glue group exhibited a trend towards higher complete healing (39.06%) than bFGF alone (25.28%) or positive controls (16.58%), but differences were not significant.
Complete healing was significantly favored over unfavorable healing in negative, positive, and bFGF-only groups, but not in the bFGF/fibrin glue group.

Conclusions:

Topical bFGF with fibrin glue demonstrated an insignificantly higher occurrence of complete healing in delayed-replanted monkey teeth.
Further research may explore optimizing bFGF delivery for enhanced regenerative outcomes in dental trauma.