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Updated: Aug 19, 2026

Defining the Program of Maternal mRNA Translation during In vitro Maturation using a Single Oocyte Reporter Assay
Published on: June 16, 2021
How to make an egg: transcriptional regulation in oocytes
1Department of Molecular and Cell Biology and Biochemistry, Brown University, 69 Brown Street, Box G-J4, Providence, RI 02912, USA.
Abstract:
The oocyte is a highly differentiated cell. It makes organelles specialized to its unique functions and progresses through a series of developmental stages to acquire a fertilization competent phenotype. This review will integrate the biology of the oocyte with what is known about oocyte-specific gene regulation and transcription factors involved in oocyte development. We propose that oogenesis is reliant on a dynamic gene regulatory network that includes oocyte-specific transcriptional regulators.
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