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[Study on the relationship between regulatory T cells and unexplained recurrent spontaneous abortion]
1Department of Obstetrics and Gynecology, Renji Hospital of Shanghai Second Medical University, Shanghai 200001, China.
Objective:
To investigate the relationship between CD(4)(+)CD(25)(+) regulatory T cells (CD(4)(+)CD(25)(+)Tr) and unexplained recurrent spontaneous abortion (URSA).
Methods:
The expression rate of CD(4)(+)CD(25)(+)Tr in peripheral blood was determined by double-label flow cytometric analysis. The samples were taken from 20 normal non-pregnancy women, 17 URSA women and 20 normal pregnancy women.
Results:
The expression frequency of CD(4)(+)CD(25)(+)Tr cells was decreased significantly (P < 0.01) in URSA women [(11.9 +/- 2.7)%] than that in normal non-pregnancy women [(15.2 +/- 3.0)%], however, there was no significant difference between normal pregnancy women [(14.4 +/- 4.8)%] and normal non-pregnancy women (P > 0.05).
Conclusion:
The results suggest that downregulation of CD(4)(+)CD(25)(+)Tr may be associated with URSA.