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Related Experiment Videos

Interferon-induced depression: prevalence and management.

A Scalori1, M Pozzi, V Bellia

  • 1Department of Medicine, University of Milano-Bicocca, S. Gerardo Hospital, Monza, Italy.

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|March 1, 2005
PubMed
Summary
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Interferon therapy can cause depression, but the Minnesota Multiphasic Personality Inventory can help identify at-risk patients early. Prompt treatment with antidepressants is effective for managing these psychiatric side effects.

Area of Science:

  • Hepatology
  • Psychiatry
  • Clinical Psychology

Background:

  • Hepatitis C treatment with interferon and ribavirin can lead to depression in 0-50% of patients.
  • Predicting depression risk based solely on interferon schedule or psychiatric history is unreliable.

Purpose of the Study:

  • Assess depression prevalence during interferon therapy.
  • Evaluate the Minnesota Multiphasic Personality Inventory (MMPI) for early depression risk identification.
  • Determine effective treatments for interferon-induced depression.

Main Methods:

  • 185 patients with chronic hepatitis C undergoing interferon and ribavirin therapy were studied.
  • Pre-therapy assessment included MMPI and clinical examination for depressive symptoms.

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Main Results:

  • 31 patients (16.8%) developed psychiatric disorders, with 11 requiring antidepressants.
  • MMPI positive tests identified 16/18 patients who developed psychiatric disorders (sensitivity 0.58 for any disorder, 0.73 for severe).
  • MMPI demonstrated high specificity (0.99) in identifying patients who did not develop side effects. Severe psychiatric disorders responded well to antidepressant treatment.

Conclusions:

  • Psychiatric side effects are common during interferon therapy.
  • Pre-treatment psychiatric evaluation is recommended for all patients.
  • Aggressive treatment of depression, particularly with selective serotonin re-uptake inhibitors, is effective.